Endocrine Abstracts

A 69-year-old lady presented to the ophthalmologists in view of a right 6th cranial nerve palsy and headache. Neuroimaging showed a central and right sided base of skull tumour with involvement of multiple cranial nerves (3rd, 4th, 6th). An endoscopic biopsy was inconclusive. She presented to the medical team few days later with drowsiness, lethargy, and her sodium was found to be 117 mmol/l with a potassium of 5.5 mmol/l. Serum osmolality was 267 mOsm/kg, urine osmolality was...

A 42-year-old lady, with a diagnosis of Graves’ disease presented with a day’s history of fever, cough, coryzal symptoms and diarrhoea. Being diagnosed with Graves’ disease in 2015, she had been poorly compliant with ATDs. Prior to this presentation, her last FT4 was 31.4 pmo/l with a suppressed TSH. She was intermittently taking propylthiouracil (was intolerant of carbimazole). She had refused RAI and preferred surgery, but hadn’t been keeping up with her ...

Case History: A 64-year-old gentleman presented with progressive exertional breathlessness since 1 year. He had started noticing pigmentation in the eyes 2 years back, and gave a history of passing black coloured urine since childhood. He had never consulted a medical professional for the same. Examination revealed hyperpigmentation of both ears and conjunctivae, and an ejection systolic murmur (Grade V) at the aortic area, which radiated to both his carotids. A sample of his ...

Case history: A 50-year-old lady, on Lithium for 30 years, presented with a history of progressively increasing thirst since 12 months; associated with polyuria and nocturia. She had been having some joint aches and was finding it more difficult to get up and down stairs. She was found to be hypothyroid few months back and prior to that had been falling asleep easily. There had been an improvement in her energy levels after starting Levothyroxine. She gave no history of renal ...

Case History: A 74-year-lady with a background of COPD presented to the emergency department with precordial chest pain radiating to the left arm. The pain had been ongoing since a few hours, and was associated with diaphoresis. She was hemodynamically stable, with no tachycardia Investigations: ECG showed significant ST-segment elevations, predominantly in the chest leads, with elevated troponins. Assuming it to be STEMI, she was transferred to the tert...

A 76-year-old lady with a background of Crohn’s disease (ileostomy in 1991) was referred to endocrinology in March 2022. Her 9-am cortisol level was <50 nmol/l, with a sodium of 130 mmol/l. These were done as she reported tiredness, lethargy and dizziness since November 2021. She had also lost 7 lb of weight. No evidence of hyperpigmentation. She had then been empirically started on hydrocortisone (10 mg-morning, 5 mg-afternoon and 5 mg-evening) pending evaluation of ...

Introduction: Teriparatide is an osteoanabolic agent approved for the treatment of osteoporosis in postmenopausal women, in men with increased fracture risk, and in glucocorticoid-induced osteoporosis. The aim of this study was to evaluate the real-world use and efficacy of teriparatide.Patients and Methods: We retrospectively assessed all patients with available data, who received teriparatide at Leeds Teaching Hospital...